PolyPhil vs. PolyPhil Next: which variant for which skin?

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In short: The difference is the hyaluronic acid. PolyPhil™ contains pure polynucleotides (20 mg/ml) and stands for regeneration and skin quality. PolyPhil™ Next combines polynucleotides with hyaluronic acid (10 mg/ml each) – for mature or dehydrated skin that needs extra moisture. There is also PolyPhil™ Eye, specifically for the delicate eye area. Which variant is suitable depends on whether your skin primarily needs regeneration or regeneration plus moisture.

When you choose PolyPhil™ If you're interested, you'll quickly come across three names – and the question of which one is the right one. We'll explain the difference so that it sticks.

All three are based on the same active ingredient

First, the commonality: all PolyPhil™ variants are polynucleotide skin boosters from the Austrian brand Croma-Pharma, manufactured by Mastelli in Italy. The core is always the same – highly pure polynucleotides that stimulate the skin's own repair cells. None of these variants are fillers; none create artificial volume.

The difference lies in what is additionally included and for which zone the formula is intended.

PolyPhil™ — the pure build-up formula

PolyPhil™ contains 20 mg/ml pure polynucleotides, without hyaluronic acid. This is the variant for skin quality and structure: it stimulates collagen and elastin, improves skin density and texture, and is well suited for thin, sun-damaged skin, as well as for support during Acne scars.

It's useful if your skin primarily needs renewal, and the moisture level is generally okay.

PolyPhil™ Next — Regeneration and Moisture

PolyPhil™ Next combines 10 mg/ml polynucleotides with 10 mg/ml hyaluronic acid. The idea: biostimulation and immediate hydration in one step. The polynucleotides stimulate the cells, while the hyaluronic acid provides direct hydration.

This variant is made for mature or dehydrated skin, which needs both simultaneously – building up from within and a moisture boost. Those who feel their skin appears dull and tired in texture often find this to be the right choice.

PolyPhil™ Eye — for the eye area

The skin around the eyes is thinner and more delicate than on the rest of the face. PolyPhil™ Eye is specially formulated for this zone and works with adapted concentrations. The aim is firmness and hydration for tired, thin eye areas. More on this in the article Hyaluronic acid injections under the eyes.

The comparison at a glance

PolyPhil™PolyPhil™ NextPolyPhil™ Eye
Active ingredient20 mg/ml polynucleotides10 mg/ml PN + 10 mg/ml HA7.5 mg/ml Polynucleotides
FocusStructure, skin qualityRegeneration + moistureEyelid skin firmness
Ideal forThin, sun-damaged skin, acne scarsMature, dehydrated skinTired, thin eye area
VolumeNoNoNo

How we choose the variety

In the alestetics® At our clinic in Zurich, we don't determine the variant by trend, but by your skin's condition. We administer all three with the Vital Injector 2™ – without welt or micro-papules. Often, only a close look at moisture, density, and zone will determine which formula is suitable.

This view is provided by the free AURA 3D Skin Analysis. Prices can be found on the PolyPhil™ Page.

Read on

What is the difference between PolyPhil and PolyPhil Next?

PolyPhil contains pure polynucleotides (20 mg/ml) and stands for structure and skin quality. PolyPhil Next combines polynucleotides with hyaluronic acid (10 mg/ml each) and also provides moisture — ideal for mature or dehydrated skin.

Which PolyPhil variant is right for me?

This depends on your skin condition: pure regeneration calls for PolyPhil, regeneration plus moisture for PolyPhil Next, and the eye area for PolyPhil Eye. Which one is right for you will be determined individually.

Does PolyPhil contain hyaluronic acid?

Reines PolyPhil contains no hyaluronic acid, only polynucleotides. PolyPhil Next combines polynucleotides with hyaluronic acid for added moisture.

Is PolyPhil a filler?

No. All PolyPhil variants are skin boosters that stimulate cell renewal. They do not create artificial volume and do not alter facial features.

PolyPhil

PolyPhil is a brand of Croma-Pharma from Austria. Mastelli in Sanremo, Italy, is listed as the manufacturer on the packaging.

Alexandra Stroganova – Founder of alestetics® Zurich

Written by

Alexandra Stroganova

Founder of alestetics® · Pre-ageing specialist

Medical beautician · V-NISSG-certified · Lymphatic therapist · since 2021

Alexandra founded alestetics® in Zurich in 2021. She works according to the ‘pre-ageing’ philosophy: improving skin quality early on, rather than trying to conceal it later.

Find out more about Alexandra and the team →
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