Plinest or PolyPhil? The concrete comparison – and the matter with Mastelli
In short: If you're looking for Plinest in Switzerland and can't find it, it's not your fault. Mastelli, the Italian manufacturer of Plinest, simply doesn't distribute directly here. What is available is PolyPhil – and its packaging lists Mastelli as the manufacturer. So, both product lines grow from the same root: PN-HPT® technology from Sanremo. They have different names, different compositions, and yet they come from the same company. Further down, we'll compare the formulas in detail.
It happens more often than you think: a client sits with us and says „I want Plinest.» They know it from Russia or abroad, where polynucleotides are known by exactly that name. And then the surprise – Plinest is hardly to be found in Switzerland. This causes uncertainty. So we clarify this calmly, with the actual facts.
Why there are hardly any Plinths in Switzerland
Whether a medical device is offered in a country has less to do with its quality than with distribution channels and approvals. Mastelli strongly distributes Plinest in many markets – in Italy, the rest of Europe, and Russia. This direct route is currently not available for Switzerland.
That doesn't mean Mastelli's polynucleotides aren't here. It just means they go by a different name.
A brief note on Mastelli – because the story is truly lovely
Mastelli was founded in 1952 in Sanremo, Italy, and the company is at the forefront of the entire polynucleotide concept. Its roots lie in wound healing: it was recognised early on that purified DNA fragments promote tissue regeneration. This decades-long work led to the PN-HPT® purification technology, which allows for the particularly pure extraction of polynucleotides—with as few proteins as possible that could trigger reactions.
In brief: If „salmon DNA» and skin regeneration are being discussed worldwide today, a large part of the trail leads back to Sanremo. Mastelli is the pioneer, and a large part of the scientific foundation stems from this work. You can find the full range on the Mastelli Aesthetic Medicine Website.
And where does PolyPhil come into play?
PolyPhil belongs to the product line of the Austrian company Croma-Pharma (their line is called PhilArt). Croma is a well-known brand in minimally invasive aesthetics, present in over 70 countries. So far, so familiar.
The beauty comes when you turn the box over. The PolyPhil packaging itself states Mastelli in Sanremo as the manufacturer – this is not a marketing claim, you can read that in black and white there. And Croma confirms in its own documents that the manufacturing is based on PN-HPT® technology. Exactly the technology that Mastelli developed.
This makes things clear: PolyPhil and Plinest are independent products with their own formulations and names – but they come from the same company and the same technology. Anyone who gets PolyPhil in Switzerland is getting polynucleotides from the pioneer's workshop. Not a substitute, not an imitation, but the same origin under a different label.
I am deliberately not saying that Plinest and PolyPhil are identical – that would simply be wrong. The formulations differ. That's precisely why a closer look is worthwhile.
The concrete comparison: same idea, built in parallel
What is noticeable when you place the two series side by side: they are almost mirror images of each other. For every Plinest product, there is a PolyPhil counterpart with the same task. Here are the formulas, as concrete as possible:
| Task | Plinest-Range (Mastelli) | PolyPhil-Range (Croma-Pharma) |
|---|---|---|
| Pure polynucleotides, face | Plinest — Purified polynucleotides (PN-HPT®), 2ml pre-filled syringe | PolyPhil — 20 mg/ml long-chain polynucleotides, 2 ml pre-filled syringe |
| Polynucleotides + Hyaluronic acid | Newest Nucleotides + Hyaluronic acid + Mannitol | PolyPhil Next Polynucleotides + Hyaluronic acid |
| For the eye area | Plinest Eye | PolyPhil Eye |
| Widespread / Body | Plinest One (Solution, ampoules) | possible via PolyPhil |
| Pure Hyaluronic Acid | I ALL WAIT | — |
A few things are worth explaining because they are often confused:
The pure polynucleotide is the core of both ranges. Plinest and PolyPhil contain polynucleotides without hyaluronic acid – their job is cell renewal, not immediate hydration. PolyPhil is indicated at 20 mg/ml; Plinest is in a comparable range. Both are administered intradermally via a 2 ml pre-filled syringe.
The variant with hyaluronic acid means at Mastelli Newest, at Croma PolyPhil Next. Here hyaluronic acid is added to the polynucleotide – regeneration plus immediate moisture in one step. Newest also contains mannitol, an antioxidant. This option is better suited for mature or dehydrated skin.
The eye variant is there with both with an adjusted, gentler formula — Plinest Eye and PolyPhil Eye. The thin eyelid skin needs it. More on this in Hyaluronic acid injections under the eyes.
And a common misconception to finish: I ALL WAIT from the Mastelli range none Polynucleotide, but pure hyaluronic acid. So anyone who means „the Mastelli product with hyaluronic acid» almost always means Newest – not iALEST.
Crucially, across all variants: none of these products are fillers. They are skin boosters that stimulate the skin to regenerate — they do not create artificial volume. How this fundamentally relates to hyaluronic acid, you can read about in Polynucleotides or hyaluron, and you'll find the entire brand landscape in the Brand comparison.
Which means for your treatment in Zurich
If you've been fixated on the name Plinest until now, you can rest assured: With PolyPhil, you get polynucleotides in Zurich with precisely this PN-HPT® origin, regularly available in Switzerland. It's not about replacing a name, but about choosing the right formula for your skin — pure polynucleotide, the variant with hyaluronic acid, or the eye variant.
In the alestetics® Working at a clinic directly at Zurich HB, we work with PolyPhil™ and bring it in with the Vital Injector 2™ — without wheals and micropapules. We will look at which variant suits your skin condition together in the free AURA 3D Skin Analysis to.
Read on
- Plinest, PolyPhil, Rejuran, Nucleofill in comparison
- PolyPhil vs. PolyPhil Next: which variant for which skin?
- Polynucleotides or hyaluronic acid: what is better for skin quality?
Is Plinest available in Switzerland?
Mastelli, the manufacturer of Plinest, does not currently sell directly in Switzerland. However, Mastelli's polynucleotides are available here as PolyPhil from Croma, on whose packaging Mastelli is listed as the manufacturer.
Is PolyPhil the same as Plinest?
No, they are independent products with different formulations. What they have in common is their origin: both are based on PN-HPT® technology and are manufactured at Mastelli. PolyPhil is distributed through the Austrian company Croma-Pharma.
What is the difference between Newest and PolyPhil Next?
Both combine polynucleotides with hyaluronic acid — Newest belongs to the Mastelli range (with added mannitol as an antioxidant), PolyPhil Next to the Croma range. The idea is the same: regeneration plus hydration.
What is the concentration of PolyPhil?
PolyPhil contains long-chain polynucleotides at a concentration of 20 mg/ml, in a 2 ml pre-filled syringe. Plinest is of a comparable magnitude.
Does PolyPhil contain hyaluronic acid?
The pure PolyPhil contains only polynucleotides. The PolyPhil Next variant combines polynucleotides with hyaluronic acid as well — comparable to Newest from the Mastelli range.
