{"id":6741,"date":"2026-07-11T07:46:24","date_gmt":"2026-07-11T05:46:24","guid":{"rendered":"https:\/\/alestetics.ch\/?p=6741"},"modified":"2026-07-09T07:53:19","modified_gmt":"2026-07-09T05:53:19","slug":"plinest-oder-polyphil-2","status":"publish","type":"post","link":"https:\/\/alestetics.ch\/en\/plinest-oder-polyphil-2\/","title":{"rendered":"Plinest or PolyPhil? The concrete comparison \u2013 and the matter with Mastelli"},"content":{"rendered":"<h1 class=\"wp-block-heading\">Plinest or PolyPhil? The concrete comparison \u2013 and the matter with Mastelli<\/h1>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>In short:<\/strong> If you're looking for Plinest in Switzerland and can't find it, it's not your fault. Mastelli, the Italian manufacturer of Plinest, simply doesn't distribute directly here. What is available is PolyPhil \u2013 and its packaging lists Mastelli as the manufacturer. So, both product lines grow from the same root: PN-HPT\u00ae technology from Sanremo. They have different names, different compositions, and yet they come from the same company. Further down, we'll compare the formulas in detail.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">It happens more often than you think: a client sits with us and says \u201eI want Plinest.\u00bb They know it from Russia or abroad, where polynucleotides are known by exactly that name. And then the surprise \u2013 Plinest is hardly to be found in Switzerland. This causes uncertainty. So we clarify this calmly, with the actual facts.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Why there are hardly any Plinths in Switzerland<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Whether a medical device is offered in a country has less to do with its quality than with distribution channels and approvals. Mastelli strongly distributes Plinest in many markets \u2013 in Italy, the rest of Europe, and Russia. This direct route is currently not available for Switzerland.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">That doesn't mean Mastelli's polynucleotides aren't here. It just means they go by a different name.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">A brief note on Mastelli \u2013 because the story is truly lovely<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Mastelli was founded in 1952 in Sanremo, Italy, and the company is at the forefront of the entire polynucleotide concept. Its roots lie in wound healing: it was recognised early on that purified DNA fragments promote tissue regeneration. This decades-long work led to the PN-HPT\u00ae purification technology, which allows for the particularly pure extraction of polynucleotides\u2014with as few proteins as possible that could trigger reactions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In brief: If \u201esalmon DNA\u00bb and skin regeneration are being discussed worldwide today, a large part of the trail leads back to Sanremo. Mastelli is the pioneer, and a large part of the scientific foundation stems from this work. You can find the full range on the <a href=\"https:\/\/www.mastelli.com\/therapeutic-areas\/aesthetic-medicine-area\" target=\"_blank\" rel=\"noopener\">Mastelli Aesthetic Medicine Website<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">And where does PolyPhil come into play?<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">PolyPhil belongs to the product line of the Austrian company Croma-Pharma (their line is called PhilArt). Croma is a well-known brand in minimally invasive aesthetics, present in over 70 countries. So far, so familiar.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The beauty comes when you turn the box over. The PolyPhil packaging itself states Mastelli in Sanremo as the manufacturer \u2013 this is not a marketing claim, you can read that in black and white there. And Croma confirms in its own documents that the manufacturing is based on PN-HPT\u00ae technology. Exactly the technology that Mastelli developed.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">This makes things clear: PolyPhil and Plinest are independent products with their own formulations and names \u2013 but they come from the same company and the same technology. Anyone who gets PolyPhil in Switzerland is getting polynucleotides from the pioneer's workshop. Not a substitute, not an imitation, but the same origin under a different label.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">I am deliberately not saying that Plinest and PolyPhil are identical \u2013 that would simply be wrong. The formulations differ. That's precisely why a closer look is worthwhile.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">The concrete comparison: same idea, built in parallel<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">What is noticeable when you place the two series side by side: they are almost mirror images of each other. For every Plinest product, there is a PolyPhil counterpart with the same task. Here are the formulas, as concrete as possible:<\/p>\n\n\n\n<figure class=\"wp-block-table\"><table class=\"has-fixed-layout\"><thead><tr><th>Task<\/th><th>Plinest-Range (Mastelli)<\/th><th>PolyPhil-Range (Croma-Pharma)<\/th><\/tr><\/thead><tbody><tr><td><strong>Pure polynucleotides, face<\/strong><\/td><td><strong>Plinest<\/strong> \u2014 Purified polynucleotides (PN-HPT\u00ae), 2ml pre-filled syringe<\/td><td><strong>PolyPhil<\/strong> \u2014 20 mg\/ml long-chain polynucleotides, 2 ml pre-filled syringe<\/td><\/tr><tr><td><strong>Polynucleotides + Hyaluronic acid<\/strong><\/td><td><strong>Newest<\/strong> Nucleotides + Hyaluronic acid + Mannitol<\/td><td><strong>PolyPhil Next<\/strong> Polynucleotides + Hyaluronic acid<\/td><\/tr><tr><td><strong>For the eye area<\/strong><\/td><td><strong>Plinest Eye<\/strong><\/td><td><strong>PolyPhil Eye<\/strong><\/td><\/tr><tr><td><strong>Widespread \/ Body<\/strong><\/td><td><strong>Plinest One<\/strong> (Solution, ampoules)<\/td><td>possible via PolyPhil<\/td><\/tr><tr><td><strong>Pure Hyaluronic Acid<\/strong><\/td><td><strong>I ALL WAIT<\/strong><\/td><td>\u2014<\/td><\/tr><\/tbody><\/table><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">A few things are worth explaining because they are often confused:<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The pure polynucleotide<\/strong> is the core of both ranges. Plinest and PolyPhil contain polynucleotides without hyaluronic acid \u2013 their job is cell renewal, not immediate hydration. PolyPhil is indicated at 20 mg\/ml; Plinest is in a comparable range. Both are administered intradermally via a 2 ml pre-filled syringe.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The variant with hyaluronic acid<\/strong> means at Mastelli <em>Newest<\/em>, at Croma <em>PolyPhil Next<\/em>. Here hyaluronic acid is added to the polynucleotide \u2013 regeneration plus immediate moisture in one step. Newest also contains mannitol, an antioxidant. This option is better suited for mature or dehydrated skin.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The eye variant<\/strong> is there with both with an adjusted, gentler formula \u2014 <em>Plinest Eye<\/em> and <em>PolyPhil Eye<\/em>. The thin eyelid skin needs it. More on this in <a href=\"\/en\/polynukleotide-augenringe\/\">Hyaluronic acid injections under the eyes<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">And a common misconception to finish: <em>I ALL WAIT<\/em> from the Mastelli range <strong>none<\/strong> Polynucleotide, but pure hyaluronic acid. So anyone who means \u201ethe Mastelli product with hyaluronic acid\u00bb almost always means Newest \u2013 not iALEST.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Crucially, across all variants: none of these products are fillers. They are skin boosters that stimulate the skin to regenerate \u2014 they do not create artificial volume. How this fundamentally relates to hyaluronic acid, you can read about in <a href=\"\/en\/polynukleotide-oder-hyaluron\/\">Polynucleotides or hyaluron<\/a>, and you'll find the entire brand landscape in the <a href=\"\/en\/polynukleotide-marken-vergleich\/\">Brand comparison<\/a>.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Which means for your treatment in Zurich<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">If you've been fixated on the name Plinest until now, you can rest assured: With PolyPhil, you get polynucleotides in Zurich with precisely this PN-HPT\u00ae origin, regularly available in Switzerland. It's not about replacing a name, but about choosing the right formula for your skin \u2014 pure polynucleotide, the variant with hyaluronic acid, or the eye variant.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In the <a href=\"\/en\/\">alestetics\u00ae<\/a> Working at a clinic directly at Zurich HB, we work with <a href=\"\/en\/polyphil-skinbooster-polynucleotid\/\">PolyPhil\u2122<\/a> and bring it in with the Vital Injector 2\u2122 \u2014 without wheals and micropapules. We will look at which variant suits your skin condition together in the free <a href=\"https:\/\/www.fresha.com\/de\/a\/alestetics-r-zurich-konradstrasse-1-sewbfvnl\/booking?allOffer=true&amp;menu=true&amp;pId=948609&amp;cartId=e64ac995-03ab-4192-bf67-d59040e4bd05\" target=\"_blank\" rel=\"noopener\">AURA 3D Skin Analysis<\/a> to.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Read on<\/strong><\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li><a href=\"\/en\/polynukleotide-marken-vergleich\/\">Plinest, PolyPhil, Rejuran, Nucleofill in comparison<\/a><\/li>\n\n\n\n<li><a href=\"\/en\/polyphil-vs-polyphil-next\/\">PolyPhil vs. PolyPhil Next: which variant for which skin?<\/a><\/li>\n\n\n\n<li><a href=\"\/en\/polynukleotide-oder-hyaluron\/\">Polynucleotides or hyaluronic acid: what is better for skin quality?<\/a><\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\"><\/p>\n\n\n<div id=\"rank-math-faq\" class=\"rank-math-block\">\n<div class=\"rank-math-list\">\n<div id=\"faq-question-1783576049218\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\"><strong>Is Plinest available in Switzerland?<\/strong> <\/h3>\n<div class=\"rank-math-answer\">\n\n<p>Mastelli, the manufacturer of Plinest, does not currently sell directly in Switzerland. However, Mastelli's polynucleotides are available here as PolyPhil from Croma, on whose packaging Mastelli is listed as the manufacturer.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1783576141613\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\"><strong>Is PolyPhil the same as Plinest?<\/strong> <\/h3>\n<div class=\"rank-math-answer\">\n\n<p>No, they are independent products with different formulations. What they have in common is their origin: both are based on PN-HPT\u00ae technology and are manufactured at Mastelli. PolyPhil is distributed through the Austrian company Croma-Pharma.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1783576153246\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\"><strong>What is the difference between Newest and PolyPhil Next?<\/strong> <\/h3>\n<div class=\"rank-math-answer\">\n\n<p>Both combine polynucleotides with hyaluronic acid \u2014 Newest belongs to the Mastelli range (with added mannitol as an antioxidant), PolyPhil Next to the Croma range. The idea is the same: regeneration plus hydration.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1783576168413\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\"><strong>What is the concentration of PolyPhil?<\/strong><\/h3>\n<div class=\"rank-math-answer\">\n\n<p> PolyPhil contains long-chain polynucleotides at a concentration of 20 mg\/ml, in a 2 ml pre-filled syringe. Plinest is of a comparable magnitude.<\/p>\n\n<\/div>\n<\/div>\n<div id=\"faq-question-1783576180912\" class=\"rank-math-list-item\">\n<h3 class=\"rank-math-question\"><strong>Does PolyPhil contain hyaluronic acid?<\/strong> <\/h3>\n<div class=\"rank-math-answer\">\n\n<p>The pure PolyPhil contains only polynucleotides. The PolyPhil Next variant combines polynucleotides with hyaluronic acid as well \u2014 comparable to Newest from the Mastelli range.<\/p>\n\n<\/div>\n<\/div>\n<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>Plinest oder PolyPhil? Der konkrete Vergleich \u2013 und die Sache mit Mastelli Kurz gesagt: Wenn du in der Schweiz nach Plinest suchst und nicht f\u00fcndig wirst, liegt das nicht an [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":6246,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[15],"tags":[19],"class_list":["post-6741","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-gesicht","tag-facial"],"_links":{"self":[{"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/posts\/6741","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/comments?post=6741"}],"version-history":[{"count":1,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/posts\/6741\/revisions"}],"predecessor-version":[{"id":6742,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/posts\/6741\/revisions\/6742"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/media\/6246"}],"wp:attachment":[{"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/media?parent=6741"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/categories?post=6741"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/alestetics.ch\/en\/wp-json\/wp\/v2\/tags?post=6741"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}