{"id":6737,"date":"2026-07-10T07:16:53","date_gmt":"2026-07-10T05:16:53","guid":{"rendered":"https:\/\/alestetics.ch\/?p=6737"},"modified":"2026-07-09T07:25:03","modified_gmt":"2026-07-09T05:25:03","slug":"was-sind-polynukleotide","status":"publish","type":"post","link":"https:\/\/alestetics.ch\/en\/was-sind-polynukleotide\/","title":{"rendered":"What are polynucleotides? Effects, origin and process"},"content":{"rendered":"

In short:<\/strong> Polynucleotides are highly purified fragments of DNA \u2013 long chains of the building blocks that also make up our own genetic material. When introduced into the skin, they stimulate fibroblasts, which are the cells that produce collagen and elastin. The result is a gradual improvement in moisture, elasticity, and skin texture. They are obtained from natural sources \u2013 mostly from fish, which is why they are often referred to as \u201esalmon DNA.\u00bb.<\/p>\n\n\n\n

Nucleotides are one of the biggest trends in modern skin medicine. And yet, hardly anyone understands what's precisely behind it. We'll go through it from the very beginning \u2013 as if you'd heard the term for the first time today.<\/p>\n\n\n\n

The name sounds complicated \u2013 the idea is simple<\/h2>\n\n\n\n

\u201ePoly\u00bb means many, and \u201enucleotides\u00bb are the basic building blocks of DNA. A polynucleotide is therefore a long chain of these building blocks \u2013 essentially a piece of purified genetic material.<\/p>\n\n\n\n

This might sound strange at first. But your body is made up of exactly these molecules. They are not a synthetic foreign substance, but body-identical building blocks that provide the skin with two things: material and a signal. The material serves as building material, the signal awakens the skin's own repair cells.<\/p>\n\n\n\n

Where does \u201esalmon DNA\u00bb come from \u2013 and what's the deal with \u201esalmon sperm\u00bb?<\/h2>\n\n\n\n

It's worth taking an honest look here, because terms like \u201esalmon DNA treatment\u00bb or even \u201esalmon sperm\u00bb are circulating online. Both sound spectacular - and both have a kernel of truth.<\/p>\n\n\n\n

The DNA for polynucleotides is extracted from the seminal fluid (milt) of fish. This is particularly rich in easily processable DNA, hence the colloquial term \u201esalmon sperm\u00bb. Depending on the preparation, the DNA comes from salmon or from freshwater fish such as trout. The purification is then crucial: in an elaborate process, proteins that could trigger allergic reactions are removed. What remains is a pure, well-tolerated DNA fraction \u2013 a long way from the raw starting material.<\/p>\n\n\n\n

In short: The terms \u201esalmon DNA\u00bb and \u201esalmon sperm\u00bb describe the origin, not the finished product. What goes into the skin is a sterile, highly purified active ingredient.<\/p>\n\n\n\n

How polynucleotides work in the skin<\/h2>\n\n\n\n

The actual effect occurs on three levels:<\/p>\n\n\n\n

You awaken the fibroblasts.<\/strong> Fibroblasts are the building cells of your skin. They produce collagen, elastin, and your body's own hyaluronic acid. Over the years, they become fewer and work more slowly. Polynudeotides form a water-rich matrix in the tissue, which stimulates these cells and creates a favourable environment for them. The result: more activity, firmer, and denser skin.<\/p>\n\n\n\n

2. They bind moisture.<\/strong> Due to their structure, polynucleotides attract water. This makes the skin appear plumper and fuller from within \u2013 without any external volume being added.<\/p>\n\n\n\n

3. They calm and protect.<\/strong> Polynucleotides have antioxidant properties and dampen inflammatory responses. This offers a double benefit for sensitive or irritated skin.<\/p>\n\n\n\n

Because a real transformation process is being initiated here, the result won't be apparent overnight, but will build up over weeks \u2013 and will last correspondingly longer.<\/p>\n\n\n\n

In brief: Polynukleotide and PDRN<\/h2>\n\n\n\n

When reading, you sometimes come across the abbreviation PDRN (Polydeoxyribonucleotide). PDRN and polynucleotides are often used synonymously. Strictly speaking, they differ in the length and fraction of the DNA chains. PDRN was already approved in Italy in 1994 for wound healing \u2013 this led to its current use in skin rejuvenation. For you as a patient, the origin and purity are primarily relevant, less so the exact abbreviation.<\/p>\n\n\n\n

The uses of polynucleotides<\/h2>\n\n\n\n

The area of application is broad because it's about skin quality and not a single wrinkle:<\/p>\n\n\n\n